Changfu Zhu

Investigador

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Dades personals

Categoria: Investigador

Àrea de coneixement: Biotecnologia

Telèfon: +34 973 702694

Fax: +34 973 702690

E-mail: zhu@pvcf.udl.cat

Formació Acadèmica

· Ph.D. Northeast Normal University, Changchun, China, 1996
· M.Sc., Capital Normal University, Beijing, China, 1988
· B.Sc. Biología, Northeast Normal University, Changchun, China, 1985

Recerca

Plant Secondary Metabolism Molecular Biology, especially in cloning and functional analyses of genes involved in carotenoid biosynthetic pathway in Escherichia coli and model plants, and engineering these carotenogenic genes into agriculturally important crops in order to improve nutritional quality

Publicacions Recents

Berman U, Zorrilla-Lopez U, Sandmann G, Capell T, Christou P, Zhu C (2017) The silencing of carotenoid B-hydroxylases by RNA interference in different maize genetic backgrounds increases the b-carotene content of the endosperm. Internationa Journal of Molecular Sciences 18:2515

Berman, J; Zorrilla, U; Medina, V; Farré, G; Sandmann, G; Capell, T; Christou, P; Zhu, C (2017) The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools   Plant Cell Reports  36:933-945

Bai C., Berman J., Farre G., Capell T., Sandmann G., Christou P., Zhu C (2017) Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity. Transgenic Research 26:13-23

Zhu C; Farre G; Zanga D; Lloveras J; Michelena A; Ferrio JP; Voltas J; Slafer GA; Savin R; Albajes R; Eizaguirre M; Lopez C; Cantero-Martínez C; Díaz-Gómez J; Nogareda C; Moreno JA; Angulo E; Estany J; Pena RN; Tor M; Portero-Otin M; Eritja N; Arjó G; Serrano JCE; Matias-Guiu X; Twyman RM; Sandmann G; Capell T; Christou P (2018) High-carotenoid maize: development of plant biotechnology prototypes for human and animal health and nutrition   Phytochemistry Reviews  17: 195-209

Berman J, Sheng Y, Gómez Gómez L, Veiga T, Ni X, Farre G, Capell T, Guitian J, Guitian P, Sandmann G, Christou P Zhu C, (2016) Red anthocyanins and yellow carotenoids form the color of orange-flower gentian (Gentiana lutea L. var. aurantiaca) PLoS ONE doi:10.1371/journal.pone.0162410.

Bai C., Twyman R., Farre G., Sanahuja G., Christou P., Capell T., Zhu C. 2011. A golden era - pro-vitamin A enhancement in diverse crops. In Vitro Cellular & Developmental Biology-Plant 47:205–221.

Farre G., Twyman R., Zhu C., Capell T., Christou P. 2011. Nutritionally enhanced crops and food security: scientific achievements versus political expediency. Current Opinion in Biotechnology 22:245–251.

Yuan D., Bassie L., Sabalza M., Miralpeix B., Dashevskaya S., Farre G., Rivera S., Banakar R., Bai C., Sanahuja G., Arjo G., Avilla E., Zorrilla-Lopez U., Ugidos-Damboriena N., Lopez A., Almacellas D., Zhu C., Capell T., Hahne G., Twyman R., Christou P. 2011. The potential impact of plant biotechnology on the Millennium Development Goals. Plant Cell Reports 30(3):249-65.

Naqvi S., Zhu C., Farre G., Sandmann G., Capell T., Christou P. 2011. Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin. Plant Biotechnology Journal 9:384–393.

Naqvi S., Farre G., Zhu C., Sandmann G., Capell T., Christou P. 2011. Simultaneous expression of Arabidopsis p-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content. Transgenic Research 20(1):177-81.

Naqvi S., Ramessar K., Farre G., Sabalza M., Miralpeix B., Twyman R.M., Capell T., Zhu C., Christou P. 2010. High-value products from transgenic maize. Biotechnology Advances 29:40–53.

Naqvi S., Zhu C., Farre G., Sandmann G., Capell T., Christou P. 2010. Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin. Plant Biotechnology Journal. Pub “online”: 29 AUG 2010. DOI: 10.1111/j.1467-7652.2010.00554.x

Zhu C., Bai C., Sanahuja G., Yuan D., Farre G., Naqvi S., Shi L., Capell T., Christou P. 2010. The regulation of carotenoid pigmentation in flowers. Archives of Biochemistry and Biophysics 504(1):132-41

Farre G., Sanahuja G., Naqvi S., Bai C., Capell T., Zhu C., Christou P. 2010. Travel advice on the road to carotenoids in plant. Plant Science 166(1):28-48

Li Q., Farre G., Naqvi S., Breitenbach J., Sanahuja G., Bai C., Sandmann G., Capell T., Christou P., Zhu, C. 2010. Cloning and functional characterization of the maize carotenoid isomerase and B-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Research 19(6):1053-68.

Peremarti A., Twyman R., Gomez-Galera S., Naqvi S., Farre G., Sabalza M., Miralpeix B., Dashevskaya S., Yuan D., Ramessar K., Christou P., Zhu C., Bassie L., Capell T. 2010. Promoter diversity in multigene transformation. Plant Molecular Biology 73:363-378.

Gómez-Galera S., Rojas E., Sudhakar D., Zhu Ch., Pelacho A.M., Capell T., Christou P. 2010. Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Research 19:165-180.

Peremarti A., Bassie L., Zhu C., Christou P., Capell T. 2010. Molecular characterization of the Arginine decarboxylase gene in rice. Transgenic Research 19:785-797.

Zhu C., Naqvi S, Capell T., Christou P. 2009. Metabolic engineering of ketocarotenoid biosynthesis in higher plants. Archives of Biochemistry and Biophysics 483:182-190.

Bassie L., Zhu C., Romagosa I., Christou P., Capell T. 2008. Transgenic wheat plants expressing an oat arginine decarboxylase cDNA exhibit increases in polyamine content in vegetative tissue and seeds. Molecular Breeding, DOI 10.1007/s11032-007-9154-2.

Zhu C., Naqvi S., Gomez-Galera S., Pelacho A.M., Capell T., Christou P. 2007. Transgenic strategies for the nutritional enhancement of plants. Trends in Plant Science, 12(12):548-556.

Zhu C., Gerjets T., Sandmann G. 2007. Nicotiana glauca engineered for the production of ketocarotenoids in flowers and leaves by expressing the cyanobacterial crtO ketolase gene. Transgenic Research, 16(6):813-821.

Zhu C., Kauder F., Romer S., Sandmann G. 2007. Cloning of two individual cDNAs encoding 9-cis-epoxycarotenoid dioxygenase from Gentiana lutea, their tissue specific expression and physiological effect in transgenic tobacco. Journal of Plant Physiology, 164(2):195-204.

Gerjets T., Sandmann M., Zhu C., Sandmann G. 2007. Metabolic engineering of ketocarotenoid biosynthesis in leaves and flowers of tobacco species. Biotechnology Journal, 2(10):1263-1269.

Cervantes-Cervantes M., Gallagher C.E., Zhu C., Wurtzel E.T. 2006. Maize cDNAs expressed in endosperm encode functional farnesyl pyrophosphate synthase with geranylgeranyl pyrophosphate activity. Plant Physiology, 141(1):220-231.

Sandmann G., Zhu C., Krubasik P., Fraser P.D. 2006. The biotechnological potential of the al-2 gene from Neurospora crassa for the production of monocyclic keto hydroxyl carotenoids. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1761(9):1085-1092.

Zhu C., Chen X., Wang Y. 2004. Carotenoid biosynthesis in plants and application of its relative genes in gene engineering. Journal of Plant Physiology and Molecular Biology. 30(6):609-18.

Zhu C., Yamamura S., Nishihara M., Koiwa H., Sandmann G. 2003. cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development. Biochemica et Biophysica Acta (Gene Structure and Expression),1625(3):305-308.

Simkin A., Zhu C., Kuntz M., Sandmann G. 2003. Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves. Journal of Plant Physiology, 160(5):439-443.

Zhu C., Yamamura S., Koiwa H., Nishihara M., Sandmann G. 2002. cDNA cloning and expression of carotenogenic genes during flower development in Gentiana lutea. Plant Molecular Biology, 48(3):277-285.

He Y., Zhu C., Wang D., Kong D., Sun J. 2002. Cloning of plastid division gene GlFtsZ from Gentiana lutea and its expression in the developing petal. Progress in Natural Science, 12(8): 592-597. (*These authors contributed equally to this work).

Breitenbach J., Zhu C, Sandmann G. 2001. Bleaching herbicide norflurazon inhibits phytoene desaturase by competition with the cofactors. Journal of Agricultural and Food Chemistry, 49(11):5270-5272.




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