Paul Christou

Professor Investigador (ICREA)

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Dades personals

Categoria: Professor Investigador (ICREA)

Àrea de coneixement: Biotecnologia

Adreça: ETSEA, Edifici Principal A

Telèfon: +34 973 702831

Fax: +34 973 702690

E-mail: paul.christou@pvcf.udl.es

Personal Website: https://www.icrea.cat/Web/ScientificStaff/paul-christou-319

Formació Acadèmica

· Llicenciat en Ciències, Universitad de Londres, Chelsea College, UK, 1977
· Doctorat, Universitat de Londres, University College, UK, 1980

Experiència Professional

· 2004-actualitad, Investigador ICREA, Universitat de Lleida
· 2001-2004, Profesor, Fraunhofer Institute of Molecular Biotechnology and Applied Ecology, Schmallenberg, Aachen, Alemania
· 1998 – 1994, Profesor i Responsable de l'Unitad de Biotecnología, John Innes Centre, UK

Recerca

· Biotecnologia aplicada a la obtención de cereales resistentes al estrés abiótico como sequía y salinidad.

Docència

· TECNOLOGIES GENÈTIQUES, GENÒMIQUES I DE TRANSFORMACIÓ GENÈTICA Màster Universitari en Millora Genètica Vegetal (Reverificació 12-13)

 

Publicacions Recents

Banakar R, Alvarez-Fernandez A, Díaz-Benito P, Abadia J, Capell T, and Christou P (2018) Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium   J Exp Bot  68:4983-4995

Zhu C, Bortesi L, Baysal C, Twyman RM, Fischer R, Capell T, Schillberg S, Christou P (2017) Characteristics of genome editing mutations in cereal crops. Trends in Plant Science  22: 38-52

Bortesi, L; Zhu, C; Zischewski, J; Perez, L; Bassié, L; Nadi, R; Forni, G; Lade, S; Soto, E; Jin, X; Medina, V; Villorbina, G; Muñoz, P; Farré, G; Fischer, R; Twyman, R; Capell, T; Christou, P; Schillberg, S (2016) Patterns of CRISPR/Cas9 activity in plants, animals and microbes Plant Biotechnology Journal   14:2203-2216

Banakar; Alvarez Fernández, Á; Abadia, J; Capell, T; Christou, P (2016)  The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport. Plant Biotechnol J 15: 423-432

Sabalza M., Miralpeix B., Twyman R.M., Capell T., Christou P. 2011. EU legitimizes GM crop exclusion zones. Nature Biotechnology 29(4):315-317.

Bai C., Twyman R., Farre G., Sanahuja G., Christou P., Capell T., Zhu C. 2011. A golden era - pro-vitamin A enhancement in diverse crops. In Vitro Cellular & Developmental Biology-Plant 47:205–221.

Farre G., Twyman R., Zhu C., Capell T., Christou P. 2011. Nutritionally enhanced crops and food security: scientific achievements versus political expediency. Current Opinion in Biotechnology 22:245–251.

Yuan D., Bassie L., Sabalza M., Miralpeix B., Dashevskaya S., Farre G., Rivera S., Banakar R., Bai C., Sanahuja G., Arjo G., Avilla E., Zorrilla-Lopez U., Ugidos-Damboriena N., Lopez A., Almacellas D., Zhu C., Capell T., Hahne G., Twyman R., Christou P. 2011. The potential impact of plant biotechnology on the Millennium Development Goals. Plant Cell Reports 30(3):249-65.

Sanahuja G., Banakar R., Twyman R., Capell T., Christou P. 2011. Bacillus thuringiensis: a century of research, development and commercial applications. Plant Biotechnology Journal 9:283–300.

Naqvi S., Zhu C., Farre G., Sandmann G., Capell T., Christou P. 2011. Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin. Plant Biotechnology Journal 9:384–393.

Naqvi S., Farre G., Zhu C., Sandmann G., Capell T., Christou P. 2011. Simultaneous expression of Arabidopsis p-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content. Transgenic Research 20(1):177-81.

Naqvi S., Ramessar K., Farre G., Sabalza M., Miralpeix B., Twyman R.M., Capell T., Zhu C., Christou P. 2010. High-value products from transgenic maize. Biotechnology Advances 29:40–53.

Zhu C., Bai C., Sanahuja G., Yuan D., Farre G., Naqvi S., Shi L., Capell T., Christou P. 2010. The regulation of carotenoid pigmentation in flowers. Archives of Biochemistry and Biophysics 504(1):132-41

Farre G., Sanahuja G., Naqvi S., Bai C., Capell T., Zhu, C., Christou P. 2010. Travel advice on the road to carotenoids in plant. Plant Science 166(1):28-48

Ramessar K., Capell T., Twyman R., Christou P. 2010. Going to ridiculous lengths - European coexistence regulations for GM crops. Nature Biotechnology 28:133-136

Li Q., Farre G., Naqvi S., Breitenbach J., Sanahuja G., Bai C., Sandmann G., Capell T., Christou P., Zhu C. 2010. Cloning and functional characterization of the maize carotenoid isomerase and B-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Research 19(6):1053-68

Peremarti A., Twyman R, Gomez-Galera S., Naqvi S., Farre G., Sabalza M., Miralpeix B., Dashevskaya S., Yuan D., Ramessar K., Christou P., Zhu C., Bassie L., Capell T. 2010. Promoter diversity in multigene transformation. Plant Molecular Biology 73:363-378

Farre G., Ramessar K., Twyman R., Capell T., Christou P. 2010. The humanitarian impact of plant biotechnology: recent breakthroughs vs bottlenecks for adoption. Current Opinion in Plant Biology 13:219-225

Ramessar K., Sabalza M., Miralpeix B., Capell T., Christou P. 2010. Can Microbicides Turn the Tide Against HIV? Current Pharmaceutical Design 16:468-485

Peremarti A., Bassie L., Yuan D., Pelacho A., Christou P., Capell T. 2010. Transcriptional regulation of the rice arginine decarboxylase (Adc1) and S-adenosylmethionine decarboxylase (Samdc) genes by methyl jasmonate. Plant Physiology 48:553-559

Peremarti A., Bassie L., Zhu C., Christou P., Capell, T. 2010. Molecular characterization of the Arginine decarboxylase gene in rice. Transgenic Research 19:785-797

Gómez-Galera S., Rojas E., Sudhakar D., Zhu Ch., Pelacho A.M., Capell T., Christou P. 2010. Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Research 19:165-180

Naqvi S., Farre G., Sanahuja G., Capell T., Zhu C., Christou P. 2009. When more is better: multigene engineering in plants. Trends in Plant Science 15:48-56

Twyman R.M., Ramessar K., Quemada H., Capell T., Christou P. 2009. Plant biotechnology: the importance of being accurate. Trends in Biotechnology 27(11):609-612

Naqvi S., Zhu C., Farre G., Ramessar K., Bassie L., Breitenbachb J., Perez Conesa. D., Ros G., Sandmann G., Capell T., Christou P. 2009. Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proceedings of the National Academy of Sciences of the United States of America 106;7762-7767

Peremarti A., Bassie L., Christou P., Capell T. 2009. Spermine facilitates recovery from drought but does not confer drought tolerance in transgenic rice plants expressing Datura stramonium S-adenosylmethionine decarboxylase. Plant Molecular Biology 70:253-264

Zhu C., Naqvi S., Breitenbach J., Sandmann G., Christou P., Capell T. 2009. Metabolic engineering of maize carotenoid in higher plants. Archives Biochemistry Biophysics. 483: 182-190

Ramessar K., Naqvi S., Dashevskaya S., Peremarti A., Yuan D., Gomez S., Rivera S., Farre G., Sabalza M., Miralpeix B., Twyman R.M., Zhu C., Bassie L., Capell T., Christou P. 2009. The Contribution of Plant Biotechnology to Food Security in the 21st Century, Nova Science Publishers, Inc, New York pp 3-72

Naqvi S., Zhu C., Farre G., Bassie L., Ramessar K., Breitenbach J., Perez-Conesa D., Ros-Berruezo G., Sandmann G., Capell T., Christou P. 2009. Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways, PNAS 106(19):7762-7767

Ramessar K., Capell T., Twyman R.M., Quemada H., Christou P. 2009. Calling the tunes on transgenic crops: the case for regulatory harmony, Mol Breeding 23:99–112

Ramessar K., Rademacher T., Sack M., Stadlmann J., Platis D., Stiegler G., Labrou N., Altmann F., Ma J., Stöger E., Capell T., Christou P. 2008. Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. PNAS of USA 105(10):3727-3732

Ramessar K., Capell T., Twyman R.M., Quemada H., Christou P. 2008. Trace and traceability a call for regulatory harmony. Nature Biotechnology 26:975-978

Ramessar K., Sabalza M., Capell T., Christou P. 2008. Maize plants: an ideal production platform for effective and safe molecular pharming. Plant Science 174(4):409-419

Ramessar K., Capell T., Christou P. 2008. olecular pharming in cereal crops. Phytochemical reviews 7:579-582

Zhu C., Naqvi S., Breitenbach J., Sandmann G., Christou P., Capell T. 2008. Reconstruction and extension of the carotenoid pathway in maize through combinatorial nuclear transformation. Carotenoid Science 12:61-62

Zhu C., Naqvi S., Breitenbach G., Sandmann J., Christou P., Capell T. 2008. Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize. PNAS of USA 105:18232-18237

Bassie, L., Zhu, C., Romagosa, I., Christou, P., Capell, T. 2008. Species-dependent plasticity of the polyamine biosynthetic pathway in transgenic wheat expressing an oat arginine decarboxylase (adc) cDNA. Molecular Breeding 22:39-50

Capell, T., Zhu,C., Bassie, L., Peremarti, A., Naqvi, S., Ramessar, R., Gomez, G., Christou, P. 2007. Background, Current Status and Future Prospects of Transgenic Crop Plant Development. Contributions to Science 3(4):531-538

Zhu, Ch., Navqvi, S., Gomez-Galera, S., Pelacho, A.M., Capell, T., Christou, P. 2007. Transgenic Strategies for the nutritional enhancement of plants. Trends in Plant Sciences 12: 548-555

Gómez-Galera, S., Pelacho, A.M., Gené, A., Capell, T., Christou, P. 2007. The Genetic Manipulation of Medicinal and Aromatic Plants. Plant Cell Reports 26: 1689-1715

Ramessar, K., Peremarti, A., Gomez-Galera, S., Naqvi, S., Moralejo, M., Muñoz, M., Capell, T., Christou, P. 2007. Biosafety and risk assessment framework for selectable marker genes in transgenic crop plants. A case of the science not supporting the politics. Transgenic Research 16:261-280

Kohli, A., Gonzales-Melendi, P., Abranches, R., Capell, T., Stoger E., Christou, P. 2006. The quest to understand the basis and mechanisms that control expression of introduced transgenes in crop plants. Plant Signal & Behavior 1:185-195

Drakakaki, G., Marcel, S., Arcalis, E., Altmann, F., Gonzalez-Melendi, P., Fischer, R., Christou, P., Stoger, E. 2006. The intracellular fate of a recombinant protein is tissue-dependent. Plant Physiol 141:578-586

Christou, P., Capell, T., Kohli, A., Gatehouse, J.A., Gatehouse, A.M.R. 2006. Recent developments and future prospects in insect pest control in transgenic crops. Trends in Plant Sci 11: 302-308

Ferry, N., Edwards, M.G., Gatehouse, J., Capell, T., Christou, P., Gatehouse, A.M.R. 2006. Transgenic Plants for Insect Pest Control. A Forward Looking Scientific Perspective. Transgenic Research 15: 13-19

Van Enckevort, L.J.G., Greco, R., Droc, G., Gagneur, C., Piffanelli, P., González, V.M., Cabot, P., Fornara, F., Berri, S., Lan, P., Rafel, M., Capell, T., Puigdomènech, P., Ouwerkerk, P.B.F., Meijer, A.H., Pe’, E., Colombo, L., Christou, P., Guiderdoni, E., Pereira, A. 2005. EU-OSTID: European Oryza sativa Transposon Insertional Database. Plant Mol. Biol. 59:99-110

Agrawal,P.K., Kohli, A., Twyman, R.M., Christou, P. 2005. Transformation of plants with multiple cassettes generates simple transgene integration patterns and high expression levels. Mol Breeding 16: 247-260.

Drakakaki, G., Marcel, S., Glahn,R.P., Lund, L., Periagh, S., Fischer, R., Christou, P., Stoger, E. 2005. Endosperm specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron. Plant Mol. Biol 59:869-880

Christou, P. 2005. Sustainable and durable insect pest resistance in transgenic crops. Information Systems for Biotechnology News Report. Agriculture and Environmental Biotechnology. August, 6-8.

Stoger, E., Sack, M., Nicholson, L., Fischer, R., Christou, P. 2005. Recent Progress in Plantibody Technology. Journal of Current Pharmaceutical Design 11: 2439-2457.

Ma, J.K-C., Barros, E., Bock, R., Christou, P., Dale, P.J., Dix, P.J., Fischer, R., Irwin, J., Mahoney, R., Pezzotti, M., Schillberg, S., Sparrow, P., Stoger, E., Twyman, R.M. 2005. The production of pharmaceutical proteins in transgenic plants - current perspectives. EMBO Reports 6: 593-599

Altpeter, F., Baisakh, N., Beachy, R., Bock, R., Capell, T., Christou, P., Daniell, H., Datta, S., Dix, P.J., Fauquet, C., Huang, N., Kohli, A., Mooibroek, H., Nicholson, L., Nguyen, T.T., Nugent, G., Raemakers, K., Romano, A., Somers, A.D., Stoger, E., Taylor, N., Visser, R. 2005. Particle bombardment and the genetic enhancement of crops: Myths and realities. Molecular Breeding 15:305-327

Wegel, E., Vallejos, R., Christou, P., Stoger, E., Shaw, P. 2005. Large scale chromatin decondensation induced in a developmentally activated transgene locus. Journal of Cell Science 118: 1021-1031

Arcalis, E., Marcel, S., Altmann, F., Drakakaki, G., Fischer, R., Christou, P., Stoger, E. 2004. Unexpected deposition patterns of recombinant proteins in post-ER compartments of wheat endosperm. Plant Physiol. 136, 3457-3466

Kohli, A., Prynne, M.Q., Miro, B., Pereira, A., Twyman, R.M., Capell, T., Christou, P. 2004. Dedifferentiation-mediated changes in transposition behavior make the Activator transposon an ideal tool for functional genomics in rice. Molecular Breeding 13: 177-191

Fiume, E., Christou, P., Giani, Silvia, Breviario, D. 2004. Introns are key regulatory elements of rice tubuline expression. Planta 218: 693-703

Fischer, R., Stöger, E., Schillberg, S., Christou, P., Twyman, R. 2004. Plant-based production of biopharmaceuticals. Current Opinion in Plant Biology 7: 1-7



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